Across TCGA pan-cancer cohorts, MIR6088 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR6088’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR6088 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR6088 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.
THCA, LUSC, and ESCA are the cancer types where MIR6088 tumor–normal differential expression is most reproducible.