Across TCGA pan-cancer cohorts, MIR6078 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR6078’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIR6078 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR6078 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
KIRP and KIRC are the cancer types where MIR6078 tumor–normal differential expression is most reproducible.