Across TCGA pan-cancer cohorts, MIR603 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR603’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR603 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR603 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.
BRCA and THCA are the cancer types where MIR603 tumor–normal differential expression is most reproducible.