Across TCGA pan-cancer cohorts, MIR576 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR576’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR576 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR576 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.
STAD, THCA, and KIRP are the cancer types where MIR576 tumor–normal differential expression is most reproducible.