Across TCGA pan-cancer cohorts, MIR571 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIR571’s most consistent transcriptional readouts.
The strongest signal is observed in rectum adenocarcinoma (READ), where MIR571 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR571 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
READ, KIRC, and HNSC are the cancer types where MIR571 tumor–normal differential expression is most reproducible.