Across TCGA pan-cancer cohorts, MIR559 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MIR559’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR559 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR559 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, BLCA, and LUAD are the cancer types where MIR559 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR559 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.