Q-omics provides the consensus-scored MIR553 profile across patient tissues and cancer cell-line models. MIR553 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, MIR553 is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, MIR553 RNA expression shows 13,016 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and HNSC as cancer lineages where MIR553 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR553 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR553 survival associations across molecular data types. MIR553 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR553 RNA expression–survival associations across cancer types. High MIR553 expression shows unfavorable associations in UVM, CESC, THCA and LGG, but favorable associations in OV and HNSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for MIR553 RNA expression.
This table summarizes MIR553 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR553. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR553 shows lower tumor expression in KICH and LUSC and higher tumor expression in HNSC, CHOL, PRAD and LIHC. The HNSC box plot shows higher MIR553 RNA expression in tumor versus normal tissue (log2 FC = +0.441, t-test p = .001).
This table shows molecular features associated with MIR553 in patient tissues and cancer cell lines. In patient samples, MIR553 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
