Across TCGA pan-cancer cohorts, MIR551A RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR551A’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIR551A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR551A is over-expressed in tumor.
HNSC are the cancer types where MIR551A tumor–normal differential expression is most reproducible.