Across TCGA pan-cancer cohorts, MIR548I2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR548I2’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR548I2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR548I2 is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.
STAD, UCEC, and LUSC are the cancer types where MIR548I2 tumor–normal differential expression is most reproducible.