Across TCGA pan-cancer cohorts, MIR548A1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR548A1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR548A1 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR548A1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where MIR548A1 tumor–normal differential expression is most reproducible.