Across TCGA pan-cancer cohorts, MIR519D RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR519D’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR519D RNA is repressed in tumor relative to normal tissue. In most cancer types MIR519D is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where MIR519D tumor–normal differential expression is most reproducible.