Across TCGA pan-cancer cohorts, MIR509-3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR509-3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR509-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR509-3 is over-expressed in tumor.
KIRC and KIRP are the cancer types where MIR509-3 tumor–normal differential expression is most reproducible.