Across TCGA pan-cancer cohorts, MIR4804 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4804’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIR4804 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4804 is over-expressed in tumor.
HNSC and LUSC are the cancer types where MIR4804 tumor–normal differential expression is most reproducible.