Across TCGA pan-cancer cohorts, MIR4801 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR4801’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR4801 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4801 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.
BRCA, THCA, and COAD are the cancer types where MIR4801 tumor–normal differential expression is most reproducible.