Across TCGA pan-cancer cohorts, MIR4794 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR4794’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR4794 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4794 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where MIR4794 tumor–normal differential expression is most reproducible.