Across TCGA pan-cancer cohorts, MIR4773-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4773-1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR4773-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4773-1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC and BRCA are the cancer types where MIR4773-1 tumor–normal differential expression is most reproducible.