Across TCGA pan-cancer cohorts, MIR4727 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4727’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR4727 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4727 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
STAD and THCA are the cancer types where MIR4727 tumor–normal differential expression is most reproducible.