Across TCGA pan-cancer cohorts, MIR4710 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR4710’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR4710 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4710 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where MIR4710 tumor–normal differential expression is most reproducible.