Across TCGA pan-cancer cohorts, MIR4701 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR4701’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MIR4701 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4701 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
LIHC, BRCA, and CHOL are the cancer types where MIR4701 tumor–normal differential expression is most reproducible.