Across TCGA pan-cancer cohorts, MIR4684 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4684’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR4684 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4684 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.
STAD and READ are the cancer types where MIR4684 tumor–normal differential expression is most reproducible.