MIR4660

Across TCGA patient cohorts, MIR4660 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,822 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MIR4660-associated GO terms across cancer lineages are rRNA 3'-end processing, RNA splicing, via endonucleolytic cleavage and ligation, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with MIR4660 in more than 10 cancer types. Because this analysis shows association rather than direction, both MIR4660-to-partner and partner-to-MIR4660 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 3'-end processing grouped by MIR4660-low versus MIR4660-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4660→partner) and Y-score (partner→MIR4660) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	rRNA 3'-end processing →	+0.050	+0.443	<.001	<.001	3	11
ESCA	RNA splicing, via endonucleolytic cleavage and ligation →	+0.056	+0.596	<.001	<.001	3	9
ESCA	Positive regulation of canonical NF-kappaB signal transduction →	+0.044	+0.411	<.001	.001	3	9
ESCA	Protein folding →	+0.045	+0.490	<.001	<.001	3	9
ESCA	rRNA metabolic process →	+0.044	+0.356	.001	.004	2	10
ESCA	Protein polyubiquitination →	+0.044	+0.364	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,822 associations by consensus.

rRNA 3'-end processing by MIR4660 expression — ESCA

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