Across TCGA pan-cancer cohorts, MIR4654 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR4654’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where MIR4654 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4654 is over-expressed in tumor.
LUAD are the cancer types where MIR4654 tumor–normal differential expression is most reproducible.