MIR4650-1

Across TCGA pan-cancer cohorts, MIR4650-1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated MIR4650-1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MIR4650-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR4650-1 expression acts as an unfavorable survival marker, although some lineages such as LAML show a favorable association.

SKCM, UVM, and LIHC are the cancer types where MIR4650-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.246	0.784	<.001	96	view →
UVM	OS	Tertile	All	0.136	0.919	<.001	63	view →
LIHC	DFS	Tertile	All	0.076	0.553	.002	63	view →
LAML	DFS	Quartile	All	0.608	0.295	<.001	40	view →
PAAD	DFS	Tertile	All	0.120	0.522	<.001	36	view →
DLBC	OS	Tertile	All	0.053	0.936	<.001	36	view →
CESC	OS	Tertile	All	0.228	0.598	<.001	36	view →
OV	DFS	Tertile	III,IV	0.453	0.548	.019	24	view →
MESO	DFS	Tertile	All	0.106	0.369	.016	18	view →
KIRC	DFS	Tertile	All	0.625	0.872	.039	6	view →
KICH	DFS	Tertile	All	0.425	0.847	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MIR4650-1–SKCM (OS)

Open the SKCM breakdown →