Across TCGA pan-cancer cohorts, MIR4632 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4632’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR4632 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4632 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KIRC and LUSC are the cancer types where MIR4632 tumor–normal differential expression is most reproducible.