Across TCGA pan-cancer cohorts, MIR4515 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4515’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where MIR4515 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4515 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
KICH and THCA are the cancer types where MIR4515 tumor–normal differential expression is most reproducible.