Across TCGA pan-cancer cohorts, MIR4500 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4500’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR4500 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4500 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
KIRC and THCA are the cancer types where MIR4500 tumor–normal differential expression is most reproducible.