MIR449C

Across TCGA pan-cancer cohorts, MIR449C RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated MIR449C data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher MIR449C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR449C expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

STAD, SKCM, and LGG are the cancer types where MIR449C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	III,IV	0.237	0.627	<.001	72	view →
SKCM	DFS	Tertile	All	0.054	0.728	<.001	27	view →
LGG	DFS	Tertile	All	0.156	0.753	<.001	27	view →
CESC	DFS	Tertile	II,III,IV	0.193	0.705	.045	18	view →
HNSC	DFS	Tertile	II,III,IV	0.211	0.557	.032	18	view →
UCEC	OS	Tertile	III,IV	0.085	0.595	.037	18	view →
KIRC	DFS	Tertile	II,III,IV	0.190	0.509	.030	12	view →
BRCA	DFS	Tertile	All	0.808	0.513	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MIR449C–STAD (DFS)

Open the STAD breakdown →