MIR4466

Across TCGA patient cohorts, MIR4466 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,760 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MIR4466-associated GO terms across cancer lineages are Positive regulation of protein binding, 3'-UTR-mediated mRNA stabilization, and Negative regulation of cyclin-dependent protein serine/threonine kinase activity. Each is linked with MIR4466 in more than 3 cancer types. Because this analysis shows association rather than direction, both MIR4466-to-partner and partner-to-MIR4466 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein binding grouped by MIR4466-low versus MIR4466-high in BRCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4466→partner) and Y-score (partner→MIR4466) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Positive regulation of protein binding →	+0.044	+0.041	<.001	<.001	3	3
STAD	3'-UTR-mediated mRNA stabilization →	+0.046	+0.316	<.001	<.001	3	3
STAD	Negative regulation of cyclin-dependent protein serine/threonine kinase activity →	+0.038	+0.267	<.001	<.001	3	3
LUSC	Diacylglycerol metabolic process →	+0.034	+0.046	.007	.003	3	3
STAD	Hematopoietic or lymphoid organ development →	+0.033	+0.338	<.001	<.001	3	3
STAD	Stem cell differentiation →	+0.027	+0.261	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,760 associations by consensus.

Positive regulation of protein binding by MIR4466 expression — BRCA

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