MIR4458HG

Across TCGA pan-cancer cohorts, MIR4458HG RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MIR4458HG data layer.

The strongest signal is observed in mesothelioma (MESO), where higher MIR4458HG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MIR4458HG expression acts as an unfavorable survival marker, although some lineages such as MESO and CESC show a favorable association.

MESO, CESC, and LIHC are the cancer types where MIR4458HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.439	0.233	.005	80	view →
CESC	DFS	Median	All	0.714	0.396	<.001	66	view →
LIHC	DFS	Tertile	All	0.389	0.631	<.001	58	view →
UCS	DFS	Median	II,III,IV	0.532	0.188	.004	56	view →
READ	DFS	Median	III,IV	0.651	0.359	.004	55	view →
KIRC	DFS	Tertile	All	0.896	0.749	<.001	48	view →
ACC	OS	Quartile	II,III,IV	0.310	1.000	.002	48	view →
UVM	DFS	Median	III,IV	0.200	0.892	.001	47	view →
LUSC	OS	Median	II,III,IV	0.495	0.337	.002	39	view →
KIRP	DFS	Median	III,IV	0.801	0.156	.008	38	view →
LGG	OS	Median	All	0.374	0.505	<.001	37	view →
STAD	DFS	Median	All	0.790	0.592	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MIR4458HG–MESO (DFS)

Open the MESO breakdown →