MIR4451

Across TCGA pan-cancer cohorts, MIR4451 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR4451’s most consistent transcriptional readouts.

The strongest signal is observed in esophageal carcinoma (ESCA), where MIR4451 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4451 is over-expressed in tumor, although a few such as ESCA and PAAD show the opposite, repressed pattern.

ESCA, PAAD, and STAD are the cancer types where MIR4451 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4451 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
ESCA	Female	All	−1.513	.002	2	view →
PAAD	Male	All	−0.720	.004	2	view →
STAD	Male	IV	−0.960	.048	1	view →
THCA	Female	All	−0.086	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MIR4451–ESCA

Open the ESCA breakdown →