MIR4449

Across TCGA patient cohorts, MIR4449 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,486 significant associations in total. READ shows the largest number of these associations.

The most reproducible MIR4449-associated GO terms across cancer lineages are tRNA thio-modification, Peptidyl-lysine monomethylation, and Protein insertion into ER membrane by stop-transfer membrane-anchor sequence. Each is linked with MIR4449 in more than 12 cancer types. Because this analysis shows association rather than direction, both MIR4449-to-partner and partner-to-MIR4449 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA thio-modification grouped by MIR4449-low versus MIR4449-high in READ.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4449→partner) and Y-score (partner→MIR4449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	tRNA thio-modification →	+0.080	+1.321	<.001	<.001	3	13
ESCA	Peptidyl-lysine monomethylation →	+0.031	+0.400	<.001	<.001	3	8
THYM	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.040	+0.274	<.001	<.001	3	8
READ	Protein histidyl modification to diphthamide →	+0.033	+1.515	<.001	<.001	3	7
UVM	Mitochondrial genome maintenance →	+0.027	+0.462	.001	<.001	2	8
LUSC	Tail-anchored membrane protein insertion into ER membrane →	+0.026	+0.164	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,486 associations by consensus.

tRNA thio-modification by MIR4449 expression — READ

Explore this box plot interactively →