MIR4445

Across TCGA pan-cancer cohorts, MIR4445 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4445’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR4445 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4445 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC and KIRP are the cancer types where MIR4445 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4445 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.338	<.001	7	view →
KIRP	All	All	−0.226	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

MIR4445–KIRC

Open the KIRC breakdown →