Across TCGA pan-cancer cohorts, MIR4427 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4427’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR4427 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4427 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
STAD and KICH are the cancer types where MIR4427 tumor–normal differential expression is most reproducible.