MIR4421

Across TCGA patient cohorts, MIR4421 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,648 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MIR4421-associated GO terms across cancer lineages are Telomere capping, Positive regulation of isotype switching to IgA isotypes, and Negative regulation of ubiquitin-dependent protein catabolic process. Each is linked with MIR4421 in more than 11 cancer types. Because this analysis shows association rather than direction, both MIR4421-to-partner and partner-to-MIR4421 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere capping grouped by MIR4421-low versus MIR4421-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4421→partner) and Y-score (partner→MIR4421) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Telomere capping →	+0.084	+0.360	<.001	<.001	3	12
DLBC	Positive regulation of isotype switching to IgA isotypes →	+0.093	+0.606	<.001	.001	2	12
STAD	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.092	+0.361	<.001	<.001	3	11
STAD	Negative regulation of telomere maintenance via telomere lengthening →	+0.080	+0.340	<.001	<.001	3	11
STAD	Mitophagy →	+0.091	+0.355	<.001	<.001	3	11
STAD	Negative regulation of gene expression, epigenetic →	+0.090	+0.343	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,648 associations by consensus.

Telomere capping by MIR4421 expression — STAD

Explore this box plot interactively →