Across TCGA pan-cancer cohorts, MIR4304 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR4304’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where MIR4304 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4304 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KICH are the cancer types where MIR4304 tumor–normal differential expression is most reproducible.