MIR4259

Across TCGA pan-cancer cohorts, MIR4259 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated MIR4259 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MIR4259 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR4259 expression acts as an unfavorable survival marker, although some lineages such as LUAD and STAD show a favorable association.

KIRC, THCA, and PAAD are the cancer types where MIR4259 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.383	0.649	<.001	111	view →
THCA	OS	Tertile	All	0.928	0.991	<.001	87	view →
PAAD	DFS	Tertile	II,III,IV	0.209	0.452	<.001	63	view →
LUAD	DFS	Tertile	II,III,IV	0.786	0.509	.011	39	view →
LGG	DFS	Tertile	All	0.495	0.838	<.001	39	view →
STAD	OS	Tertile	IV	1.000	0.277	.023	36	view →
HNSC	DFS	Tertile	IV	0.719	0.343	.014	33	view →
BLCA	OS	Tertile	III,IV	0.160	0.594	<.001	18	view →
THYM	OS	Tertile	All	0.549	0.974	.001	18	view →
PCPG	DFS	Tertile	All	0.161	0.819	.004	18	view →
LAML	DFS	Tertile	All	0.339	0.510	.025	16	view →
GBM	DFS	Tertile	All	0.071	0.288	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

MIR4259–KIRC (OS)

Open the KIRC breakdown →