MIR4258

Across TCGA pan-cancer cohorts, MIR4258 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MIR4258’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MIR4258 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4258 is over-expressed in tumor.

LUAD, KIRC, and KIRP are the cancer types where MIR4258 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4258 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.952	<.001	10	view →
KIRC	All	All	+0.478	<.001	10	view →
KIRP	All	III,IV	+0.892	<.001	9	view →
HNSC	All	All	+0.480	.001	8	view →
BLCA	All	III,IV	+1.182	.001	6	view →
LUSC	Male	All	+1.063	<.001	6	view →
LIHC	Female	All	+0.501	<.001	5	view →
CHOL	All	All	+1.515	.001	4	view →
READ	All	II,III,IV	+1.307	.009	4	view →
BRCA	Female	All	+0.310	.014	4	view →
UCEC	All	III,IV	+1.027	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MIR4258–LUAD

Open the LUAD breakdown →