Across TCGA patient cohorts, MIR421 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,140 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MIR421-associated GO terms across cancer lineages are Negative regulation of telomere maintenance, Cytosolic transport, and Negative regulation of telomere capping. Each is linked with MIR421 in more than 32 cancer types. Because this analysis shows association rather than direction, both MIR421-to-partner and partner-to-MIR421 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR421→partner) and Y-score (partner→MIR421) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Negative regulation of telomere maintenance →	+0.074	+0.661	<.001	<.001	3	33
DLBC	Cytosolic transport →	+0.059	+0.789	<.001	<.001	3	32
DLBC	Negative regulation of telomere capping →	+0.073	+0.811	<.001	<.001	3	32
DLBC	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.090	+0.714	<.001	<.001	3	32
ESCA	Protein polyubiquitination →	+0.065	+1.187	<.001	<.001	2	33
DLBC	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.061	+0.733	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,140 associations by consensus.

Exploration

MIR421 survival (RNA) · tumor vs normal (RNA) · all MIR421 data types