Across TCGA pan-cancer cohorts, MIR409 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR409’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR409 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR409 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where MIR409 tumor–normal differential expression is most reproducible.