MIR381HG

Across TCGA pan-cancer cohorts, MIR381HG RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated MIR381HG data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher MIR381HG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR381HG expression acts as an unfavorable survival marker, although some lineages such as LAML and PAAD show a favorable association.

MESO, LUSC, and DLBC are the cancer types where MIR381HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.098	0.579	.001	108	view →
LUSC	OS	Tertile	All	0.377	0.767	<.001	54	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
HNSC	OS	Tertile	IV	0.284	0.662	<.001	30	view →
KIRP	OS	Tertile	All	0.590	0.903	.007	27	view →
STAD	DFS	Tertile	All	0.397	0.570	.024	27	view →
LAML	DFS	Tertile	All	0.733	0.525	.010	24	view →
BLCA	DFS	Tertile	All	0.232	0.521	.039	18	view →
UCEC	OS	Tertile	IV	0.231	0.592	.036	18	view →
PAAD	DFS	Tertile	All	0.687	0.249	.008	15	view →
LGG	DFS	Tertile	All	0.400	0.741	<.001	15	view →
THCA	DFS	Tertile	All	0.573	0.868	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MIR381HG–MESO (OS)

Open the MESO breakdown →