Across TCGA pan-cancer cohorts, MIR378A RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MIR378A data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher MIR378A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR378A expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

PAAD, COAD, and HNSC are the cancer types where MIR378A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Quartile	All	0.344	0.679	<.001	34	view →
COAD	DFS	Median	All	0.399	0.638	.003	33	view →
HNSC	DFS	Median	All	0.764	0.655	.007	31	view →
UCS	OS	Tertile	All	0.505	0.810	.002	30	view →
BLCA	OS	Tertile	All	0.798	0.667	.007	27	view →
UVM	DFS	Median	All	0.273	0.675	.003	27	view →
READ	OS	Median	II,III,IV	0.820	0.312	.003	26	view →
STAD	DFS	Tertile	II,III,IV	0.652	0.274	.011	18	view →
TGCT	DFS	Quartile	II,III,IV	0.587	1.000	.011	18	view →
CESC	OS	Quartile	All	0.696	0.538	.025	16	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	12	view →
UCEC	DFS	Tertile	All	0.867	0.904	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

Exploration

Same gene, other analysis: MIR378A tumor-vs-normal RNA expression · all MIR378A data types