Across TCGA pan-cancer cohorts, MIR374B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MIR374B data layer compared with 1 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher MIR374B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR374B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.
UVM, KIRC, and HNSC are the cancer types where MIR374B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.