Across TCGA pan-cancer cohorts, MIR3691 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR3691’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR3691 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR3691 is over-expressed in tumor, although a few such as ESCA and THCA show the opposite, repressed pattern.
BRCA, ESCA, and THCA are the cancer types where MIR3691 tumor–normal differential expression is most reproducible.