Across TCGA pan-cancer cohorts, MIR3681HG RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MIR3681HG’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR3681HG RNA is repressed in tumor relative to normal tissue. In most cancer types MIR3681HG is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and LIHC are the cancer types where MIR3681HG tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR3681HG RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.