Across TCGA pan-cancer cohorts, MIR3649 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR3649’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MIR3649 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR3649 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
LIHC, KICH, and PAAD are the cancer types where MIR3649 tumor–normal differential expression is most reproducible.