Across TCGA pan-cancer cohorts, MIR34C RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIR34C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR34C RNA is repressed in tumor relative to normal tissue. In most cancer types MIR34C is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and UCEC are the cancer types where MIR34C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR34C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−2.080	<.001	8	view →
LUAD	Female	All	−1.980	<.001	8	view →
UCEC	All	All	−1.273	.025	2	view →
PRAD	All	All	−0.380	<.001	2	view →
KIRP	All	All	+0.089	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MIR34C RNA expression & survival · all MIR34C data types