Across TCGA pan-cancer cohorts, MIR34B RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR34B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MIR34B RNA is repressed in tumor relative to normal tissue. In most cancer types MIR34B is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and THCA are the cancer types where MIR34B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR34B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−1.435	<.001	9	view →
LUSC	Female	All	−1.277	<.001	6	view →
THCA	All	All	−0.056	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MIR34B RNA expression & survival · all MIR34B data types