Across TCGA pan-cancer cohorts, MIR326 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR326’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR326 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR326 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, LIHC, and KICH are the cancer types where MIR326 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR326 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.331	<.001	5	view →
LIHC	Female	All	+0.119	.017	2	view →
KICH	All	All	−0.159	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MIR326 RNA expression & survival · all MIR326 data types