MIR31HG

Across TCGA pan-cancer cohorts, MIR31HG RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MIR31HG’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MIR31HG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR31HG is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where MIR31HG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR31HG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.068	<.001	11	view →
KIRC	All	II,III,IV	−0.910	<.001	11	view →
LUAD	Male	All	+1.217	<.001	10	view →
HNSC	Male	All	+1.273	<.001	9	view →
COAD	All	II,III,IV	+0.639	<.001	9	view →
LUSC	Male	II,III,IV	+1.431	<.001	7	view →
KICH	All	II,III,IV	−1.312	<.001	7	view →
BRCA	Female	All	−0.553	<.001	6	view →
KIRP	Male	All	+0.805	.017	3	view →
PRAD	All	All	−0.699	<.001	2	view →
STAD	All	IV	−0.906	.047	1	view →
READ	All	All	+0.458	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MIR31HG–THCA

Open the THCA breakdown →