Across TCGA pan-cancer cohorts, MIR3158-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR3158-1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR3158-1 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR3158-1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and PRAD are the cancer types where MIR3158-1 tumor–normal differential expression is most reproducible.